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Descriptor English:   Vinca Alkaloids 
Descriptor Spanish:   Alcaloides de la Vinca 
Descriptor Portuguese:   Alcaloides de Vinca 
Synonyms English:   Alkaloids, Vinca  
Tree Number:   D03.132.436.681.827
Definition English:   A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS. 
Pharmacological Action:   Antineoplastic Agents
Tubulin Modulators
History Note English:   73 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   15153 
Unique Identifier:   D014748 

Occurrence in VHL: