Search on: VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN 
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Descriptor English:   Von Hippel-Lindau Tumor Suppressor Protein 
Descriptor Spanish:   Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau 
Descriptor Portuguese:   Proteína Supressora de Tumor Von Hippel-Lindau 
Synonyms English:   VHL Tumor Suppressor Protein
Von Hippel Lindau Tumor Suppressor Protein  
Tree Number:   D08.811.464.938.750.875
D12.776.624.776.865
Definition English:   A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME. 
Entry Combination - descr/qualif English:   Von Hippel-Lindau Tumor Suppressor Protein/deficiency use von Hippel-Lindau Disease
 
History Note English:   2006 (1995) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50588 
Unique Identifier:   D051794 

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