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Descriptor English: Doxepin
Descriptor Spanish: Doxepina
Descriptor doxepina
Scope note: Compuesto tricíclico de dibenzoxepina. Muestra una gama de acciones farmacológicas que incluyen el mantenimiento de la inervación adrenérgica. Su mecanismo de acción no está del todo comprendido, pero parece que bloquea la recaptación de neurotransmisores monoaminérgicos en las terminales presinápticas. Posee también actividad anticolinérgica y modula el antagonismo de los receptores de histamina H(1)- y H(2)-.
Descriptor Portuguese: Doxepina
Descriptor French: Doxépine
Entry term(s): Apo Doxepin
Apo-Doxepin
ApoDoxepin
Aponal
Deptran
Desidox
Doneurin
Doxepia
Doxepin Hydrochloride
Doxepin Hydrochloride, Cis-Trans Isomer Mixture (approximately 1:5)
Doxepin RPh
Doxepin beta
Doxepin-RPh
Espadox
Hydrochloride, Doxepin
Mareen
Novo Doxepin
Novo-Doxepin
Prudoxin
Quitaxon
Sinequan
Sinquan
Xepin
Zonalon
Tree number(s): D02.355.291.852.500
D03.633.300.382.393
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004316
Scope note: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Sleep Aids, Pharmaceutical
Antidepressive Agents, Tricyclic
Histamine Antagonists
Registry Number: 1668-19-5
CAS Type 1 Name: 1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N,N-dimethyl-
Public MeSH Note: 74
History Note: 74
DeCS ID: 4375
Unique ID: D004316
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Doxepin - Preferred
Concept UI M0006782
Scope note A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
Preferred term Doxepin
Deptran - Narrower
Concept UI M0485388
Preferred term Deptran
Desidox - Narrower
Concept UI M0485387
Preferred term Desidox
Doneurin - Narrower
Concept UI M0492464
Preferred term Doneurin
Doxepia - Narrower
Concept UI M0492463
Preferred term Doxepia
Doxepin beta - Narrower
Concept UI M0492460
Preferred term Doxepin beta
Doxepin Hydrochloride - Narrower
Concept UI M0330406
Preferred term Doxepin Hydrochloride
Entry term(s) Doxepin Hydrochloride, Cis-Trans Isomer Mixture (approximately 1:5)
Hydrochloride, Doxepin
Doxepin-RPh - Narrower
Concept UI M0492471
Preferred term Doxepin-RPh
Entry term(s) Doxepin RPh
Espadox - Narrower
Concept UI M0492469
Preferred term Espadox
Mareen - Narrower
Concept UI M0492468
Preferred term Mareen
Novo-Doxepin - Narrower
Concept UI M0492467
Preferred term Novo-Doxepin
Entry term(s) Novo Doxepin
Prudoxin - Narrower
Concept UI M0492466
Preferred term Prudoxin
Quitaxon - Narrower
Concept UI M0492465
Preferred term Quitaxon
Sinequan - Narrower
Concept UI M0006783
Preferred term Sinequan
Entry term(s) Sinquan
Zonalon - Narrower
Concept UI M0354084
Preferred term Zonalon
Entry term(s) Xepin
Aponal - Narrower
Concept UI M0485389
Preferred term Aponal
Apo-Doxepin - Narrower
Concept UI M0485390
Preferred term Apo-Doxepin
Entry term(s) Apo Doxepin
ApoDoxepin



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