Search on: V-FMS PROTEIN 
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Descriptor English:   Oncogene Protein gp140(v-fms) 
Descriptor Spanish:   Proteína Oncogénica gp140(v-fms) 
Descriptor Portuguese:   Proteína Oncogênica gp140(v-fms) 
Synonyms English:   fms Oncogene Product gp120
fms Oncogene Product gp140
fms Oncogene Protein gp120
fms Oncogene Protein gp140
gp120 v fms
gp120 v-fms
gp120(v-fms)
gp140 v fms
gp140 v-fms
gp140(v-fms)
v fms Protein
v-fms Protein
v-fms, gp120
v-fms, gp140  
Tree Number:   D12.776.624.664.520.750.650
D12.776.964.700.750.650
D12.776.964.775.750.650
Definition English:   Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms). 
Indexing Annotation English:   IM; coord with specific virus (IM); /drug eff /ultrastruct permitted
History Note English:   91 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   29067 
Unique Identifier:   D016281 

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