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Descriptor English: Urocortins
Descriptor Spanish: Urocortinas
Descriptor urocortinas
Entry term(s) urocortina
Scope note: Neuropéptidos de unos 40 aminoácidos que son estructuralmente similares al FACTOR LIBERADOR DE CORTICOTROPINA (CRF). A diferencia del CRF, que actúa sobre todo a través de RECEPTORES DE CRF de tipo 1, las urocortinas señalizan preferentemente a través de los receptores de CRF de tipo 2. Las urocortinas tienen amplia distribución tisular, de los peces a los mamíferos, y desempeñan diversas funciones. En los mamíferos, las urocortinas pueden inhibir la ingestión de alimentos, retrasan el vaciamiento gástrico y disminuyen el edema inducido por el calor.
Descriptor Portuguese: Urocortinas
Descriptor French: Urocortines
Entry term(s): Ucn II
Ucn III
Urocortin
Urocortin 1
Urocortin 2
Urocortin 3
Urocortin I
Urocortin II
Urocortin III
Tree number(s): D06.472.699.857
D12.644.400.837
D12.644.548.887
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054832
Scope note: Neuropeptides of about 40 amino acids which are structurally similar to CORTICOTROPIN-RELEASING FACTOR. Unlike CRF acting primarily through type 1 CRF RECEPTORS, urocortins signal preferentially through type 2 CRF receptors. Urocortins have wide tissue distribution from fish to mammals, and diverse functions. In mammals, urocortins can suppress food intake, delays gastric emptying, and decreases heat-induced edema.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Corticotropin-Releasing Hormone (1995-2007)
Public MeSH Note: 2008; UROCORTIN was indexed under CORTICOTROPIN-RELEASING HORMONE 1995-2007
History Note: 2008 (1995)
DeCS ID: 52659
Unique ID: D054832
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Urocortins - Preferred
Concept UI M0254327
Scope note Neuropeptides of about 40 amino acids which are structurally similar to CORTICOTROPIN-RELEASING FACTOR. Unlike CRF acting primarily through type 1 CRF RECEPTORS, urocortins signal preferentially through type 2 CRF receptors. Urocortins have wide tissue distribution from fish to mammals, and diverse functions. In mammals, urocortins can suppress food intake, delays gastric emptying, and decreases heat-induced edema.
Preferred term Urocortins
Urocortin 3 - Narrower
Concept UI M0394061
Preferred term Urocortin 3
Entry term(s) Ucn III
Urocortin III
Urocortin 1 - Narrower
Concept UI M0508138
Preferred term Urocortin 1
Entry term(s) Urocortin
Urocortin I
Urocortin 2 - Narrower
Concept UI M0397626
Preferred term Urocortin 2
Entry term(s) Ucn II
Urocortin II



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