Pesquisa sobre: MFN=56989 
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Descritor Inglês:   Deubiquitinating Enzyme CYLD 
Descritor Espanhol:   Enzima Desubiquitinante CYLD 
Descritor Português:   Enzima Desubiquitinante CYLD 
Sinônimos Inglês:   CYLD Protein
Cylindromatosis Protein
Deubiquitinating Enzyme Cylindromatosis
CYLD, Deubiquitinating Enzyme
Cylindromatosis, Deubiquitinating Enzyme  
Categoria:   D08.811.037.375
Definição Inglês:   A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   56989 
Identificador Único:   D000074749 

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