Pesquisa sobre: MFN=56996 
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Descritor Inglês:   Valosin Containing Protein 
Descritor Espanhol:   Proteína que Contiene Valosina 
Descritor Português:   Proteína com Valosina 
Sinônimos Inglês:   CDC48 Protein
Cell Cycle Protein CDC48
Cell Cycle Protein CDC48p
Valosin-Containing Protein
Valosine-Containing Protein
p97 Valosin-Containing Protein
Valosin-Containing Protein, p97
Valosine Containing Protein
p97 Valosin Containing Protein  
Categoria:   D08.811.
Definição Inglês:   A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients. 
Nota Histórica Inglês:   2018 (1991) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   56996 
Identificador Único:   D000074405 

Ocorrência na BVS: