Pesquisa sobre: MFN=57007 
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Descritor Inglês:   High-Temperature Requirement A Serine Peptidase 1 
Descritor Espanhol:   Serina Peptidasa A1 que Requiere Temperaturas Altas 
Descritor Português:   Serina Peptidase 1 de Requerimento de Alta Temperatura A 
Sinônimos Inglês:   Serine Protease HTRA1
HTRA1, Serine Protease
High Temperature Requirement A Serine Peptidase 1
Protease HTRA1, Serine  
Categoria:   D08.811.277.656.300.760.420
Definição Inglês:   A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL). 
Relacionados Inglês:   Kazal Motifs
PDZ Domains
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57007 
Identificador Único:   D000074289 

Ocorrência na BVS: