Pesquisa sobre: MFN=57010 
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Descritor Inglês:   X-linked Nuclear Protein 
Descritor Espanhol:   Proteína Nuclear Ligada al Cromosoma X 
Descritor Português:   Proteína Nuclear Ligada ao X 
Sinônimos Inglês:   ATRX Protein
RAD54 Homolog Protein
Homolog Protein, RAD54
Nuclear Protein, X-linked
X linked Nuclear Protein  
Categoria:   D08.811.399.340.375
Definição Inglês:   ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome). 
Relacionados Inglês:   PHD Zinc Fingers
 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57010 
Identificador Único:   D000075924 

Ocorrência na BVS:
 
MEDLINE    

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