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Descritor Inglês:   DNA (Cytosine-5-)-Methyltransferase 1 
Descritor Espanhol:   ADN (Citosina-5-)-Metiltransferasa 1 
Descritor Português:   DNA (Citosina-5-)-Metiltransferase 1 
Sinônimos Inglês:   DNMT1 Enzyme
Enzyme, DNMT1  
Categoria:   D08.811.913.555.500.350.100.500.500
Definição Inglês:   A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E. 
Relacionados Inglês:   Zinc Fingers
Nota Histórica Inglês:   2018 (1999) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57029 
Identificador Único:   D000076123 

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