Pesquisa sobre: MFN=57032 
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Descritor Inglês:   Protein Kinase C-theta 
Descritor Espanhol:   Proteína Quinasa C-theta 
Descritor Português:   Proteína Quinase C-theta 
Sinônimos Inglês:   PKC-theta
Protein Kinase C theta
Protein Kinase C, theta
PKC theta  
Categoria:   D08.811.913.696.620.682.700.725.075
Definição Inglês:   A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57032 
Identificador Único:   D000074121 

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