Pesquisa sobre: MFN=57033 
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Descritor Inglês:   WNK Lysine-Deficient Protein Kinase 1 
Descritor Espanhol:   Proteína Quinasa Deficiente en Lisina WNK 1 
Descritor Português:   Proteína Quinase 1 Deficiente de Lisina WNK 
Sinônimos Inglês:   WNK Lysine Deficient Protein Kinase 1  
Categoria:   D08.811.913.696.620.682.700.982
D12.644.360.975
D12.776.476.944
D23.050.301.500.600.962
D23.050.705.552.600.925
Definição Inglês:   A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57033 
Identificador Único:   D000076204 

Ocorrência na BVS:
 
MEDLINE    

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