Pesquisa sobre: MFN=57112 
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Descritor Inglês:   Thyroid Nuclear Factor 1 
Descritor Espanhol:   Factor Nuclear Tiroideo 1 
Descritor Português:   Fator Nuclear 1 de Tireoide 
Sinônimos Inglês:   Homeobox Protein Nkx-2.1
NK2 Homeobox 1 Protein
TITF-1 Protein
TITF1 Protein
TTF-1 Thyroid Nuclear Factor
Thyroid Transcription Factor 1
Thyroid-Specific Enhancer-Binding Protein
Enhancer-Binding Protein, Thyroid-Specific
Homeobox Protein Nkx 2.1
Nkx-2.1, Homeobox Protein
TITF 1 Protein
TTF 1 Thyroid Nuclear Factor
Thyroid Specific Enhancer Binding Protein  
Categoria:   D12.776.260.400.871
Definição Inglês:   A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY. 
Nota Histórica Inglês:   2018 (1990) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57112 
Identificador Único:   D000074482 

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