Pesquisa sobre: MFN=57117 
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Descritor Inglês:   Zinc Finger Protein Gli3 
Descritor Espanhol:   Proteína Gli3 con Dedos de Zinc 
Descritor Português:   Proteína Gli3 com Dedos de Zinco 
Sinônimos Inglês:   GLI-Kruppel Family Member 3 Protein
Glioma-Associated Oncogene Family Zinc Finger 3 Protein
GLI Kruppel Family Member 3 Protein
Glioma Associated Oncogene Family Zinc Finger 3 Protein  
Categoria:   D12.776.260.522.875
D12.776.260.703.900
D12.776.930.375.875
D12.776.930.780.972
Definição Inglês:   A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57117 
Identificador Único:   D000074290 

Ocorrência na BVS:
 
MEDLINE    

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