Pesquisa sobre: MFN=57122 
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Descritor Inglês:   Fanconi Anemia Complementation Group N Protein 
Descritor Espanhol:   Proteína del Grupo de Complementación N de la Anemia de Fanconi  
Descritor Português:   Proteína do Grupo de Complementação N da Anemia de Fanconi 
Sinônimos Inglês:   FANCN Protein
PALB2 Protein
Partner and Localizer of BRCA2 Protein  
Categoria:   D12.776.313.953
D12.776.624.776.051
D12.776.660.323
Definição Inglês:   A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57122 
Identificador Único:   D000076164 

Ocorrência na BVS:
 
MEDLINE    

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