Pesquisa sobre: MFN=57141 
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Descritor Inglês:   RUNX1 Translocation Partner 1 Protein 
Descritor Espanhol:   Proteína 1 Compañera de Translocación de RUNX1 
Descritor Português:   Proteína 1 Parceira de Translocação de RUNX1 
Sinônimos Inglês:   Eight Twenty One Protein
RUNX1T1 Protein  
Categoria:   D12.776.624.664.700.936
D12.776.930.780.625.575
Definição Inglês:   A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57141 
Identificador Único:   D000075142 

Ocorrência na BVS:
 
MEDLINE    

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