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Descritor Inglês:   PR-SET Domains 
Descritor Espanhol:   Dominios PR-SET 
Descritor Português:   Domínios PR-SET 
Sinônimos Inglês:   PR Domain
SET Domain
Domain, PR
Domain, PR-SET
Domain, SET
Domains, PR
Domains, PR-SET
Domains, SET
PR Domains
PR SET Domains
PR-SET Domain
SET Domains  
Categoria:   G02.111.570.820.709.275.750.477
Definição Inglês:   Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Número do Registro:   57255 
Identificador Único:   D000074463 

Ocorrência na BVS:
 
MEDLINE    

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