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Descriptor English: Papaverine
Descriptor Spanish: Papaverina
Descriptor papaverina
Scope note: Alcaloide que se encuentra en el opio pero que no se encuentra estrechamente relacionado con los demás alcaloides del opio en cuanto a su estructura o efectos farmacológicos. Es un relajante de acción directa de la musculatura lisa utilizado en el tratamiento de la impotencia y como vasodilatador, especialmente para la vasodilatación cerebral. El mecanismo de sus acciones farmacológicas no está claro, pero aparentemente puede inhibir las fosfodiesterasas y puede tener acciones directas sobre los canales de calcio.
Descriptor Portuguese: Papaverina
Descriptor French: Papavérine
Entry term(s): Chlorhydrate de papavérine
Tree number(s): D03.132.098.666
D03.132.577.750
D03.633.100.531.085.666
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010208
Scope note: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Phosphodiesterase Inhibitors
Vasodilator Agents
Urological Agents
Registry Number: DAA13NKG2Q
CAS Type 1 Name: Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-
DeCS ID: 10395
Unique ID: D010208
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Papavérine - Preferred
Concept UI M0015830
Preferred term Papavérine
Chlorhydrate de papavérine - Narrower
Concept UI M0331238
Preferred term Chlorhydrate de papavérine



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