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Descriptor English: Type C Phospholipases
Descriptor Spanish: Fosfolipasas de Tipo C
Descriptor fosfolipasas de tipo C
Entry term(s) fosfolipasa C
fosfolipasas tipo C
lecitinasa C
Scope note: Subclase de fosfolipasas que hidrolizan el enlace fosfoéster que se encuentra en la tercera posición de los GLICEROFOSFOLÍPIDOS. Aunque el término singular "fosfolipasa C" se refiere específicamente a una enzima que cataliza la hidrólisis de la FOSFATIDILCOLINA (EC 3.1.4.3), se utiliza habitualmente en la literatura para referirse a una amplia variedad de enzimas que catalizan específicamente la hidrólisis de los FOSFATIDILINOSITOLES.
Descriptor Portuguese: Fosfolipases Tipo C
Descriptor French: Type C Phospholipases
Entry term(s): Lecithinase C
Phospholipase C
Phospholipases C
Phospholipases, Type C
Tree number(s): D08.811.277.352.640.700.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010738
Scope note: A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.
Annotation: general; many specifics are available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.4.-
Previous Indexing: Phospholipases (1966-1979)
Public MeSH Note: 2007; see PHOSPHOLIPASE C 1986-2007, see PHOSPHOLIPASES 1980-1985
History Note: 2007(1980)
DeCS ID: 10932
Unique ID: D010738
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1979/02/22
Revision Date: 2007/07/09
Type C Phospholipases - Preferred
Concept UI M0507666
Scope note A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.
Preferred term Type C Phospholipases
Entry term(s) Phospholipases C
Phospholipases, Type C
Phospholipase C - Narrower
Concept UI M0016673
Scope note An enzyme found in the alpha-toxin of Clostridium welchii and other strains of clostridia and bacilli. It hydrolyzes glycerophosphatidates with the formation of 1,2-diacylglycerol and a phosphorylated nitrogenous base such as choline.
Preferred term Phospholipase C
Entry term(s) Lecithinase C



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