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Descriptor English: Podophyllotoxin
Descriptor Spanish: Podofilotoxina
Descriptor podofilotoxina
Entry term(s) epipodofilotoxina
Scope note: Lignano (LIGNANOS) que se encuentra en la resina PODOFILINO procedente de las raíces de las plantas PODOPHYLLUM. Es un potente veneno del huso, tóxico si se toma internamente, y que ha sido usado como catártico. Es muy irritante para la piel y membranas mucosas, tiene acciones queratolíticas, ha sido utilizado para tratar verrugas y queratosis y puede tener propiedades antineoplásicas, como algunos de sus congéneres y derivados.
Descriptor Portuguese: Podofilotoxina
Descriptor French: Podophyllotoxine
Entry term(s): Épipodophyllotoxine
Tree number(s): D02.455.426.559.389.140.450.777
D02.455.426.559.847.638.960.675
D04.615.638.960.675
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011034
Scope note: A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Annotation: /biosyn permitted if by plant
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Antineoplastic Agents, Phytogenic
Keratolytic Agents
Tubulin Modulators
Registry Number: L36H50F353
CAS Type 1 Name: Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-
DeCS ID: 11464
Unique ID: D011034
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01
Podophyllotoxine - Preferred
Concept UI M0017087
Preferred term Podophyllotoxine
Épipodophyllotoxine - Related but not broader or narrower
Concept UI M0017088
Preferred term Épipodophyllotoxine



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