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Descriptor English: Pyruvate Carboxylase
Descriptor Spanish: Piruvato Carboxilasa
Descriptor piruvato carboxilasa
Scope note: Enzima dependiente de la biotina perteneciente a la familia de las ligasas, que cataliza la adición de ANHÍDRIDO CARBÓNICO al piruvato. Se encuentra en vegetales y en animales. La deficiencia de esta enzima causa retardo psicomotor grave y ACIDOSIS LÁCTICA en los niños. EC 6.4.1.1.
Descriptor Portuguese: Piruvato Carboxilase
Descriptor French: Pyruvate carboxylase
Entry term(s): Carboxylase, Pyruvate
Tree number(s): D08.811.464.257.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011766
Scope note: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Pyruvate Carboxylase Deficiency Disease
Registry Number: EC 6.4.1.1
CAS Type 1 Name: Pyruvate:carbon-dioxide ligase (ADP-forming)
Public MeSH Note: 74
History Note: 74
Related: Pyruvate Carboxylase Deficiency Disease MeSH
DeCS ID: 12203
Unique ID: D011766
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2010/06/25
Pyruvate Carboxylase - Preferred
Concept UI M0018288
Scope note A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.
Preferred term Pyruvate Carboxylase
Entry term(s) Carboxylase, Pyruvate



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