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Descriptor English: Pyruvate Kinase
Descriptor Spanish: Piruvato Quinasa
Descriptor piruvato cinasa
Scope note: ATP:piruvato 2-O-fosfotransferasa. Fosfotransferasa que cataliza reversiblemente la fosforilación del piruvato a fosfoenolpiruvato en presencia de ATP. Existen cuatro isoenzimas (L, R, M1 y M2). La deficiencia de la enzima provoca anemia hemolítica. EC 2.7.1.40.
Descriptor Portuguese: Piruvato Quinase
Descriptor French: Pyruvate kinase
Entry term(s): L Type Pyruvate Kinase
L-Type Pyruvate Kinase
M Type Pyruvate Kinase
M-Type Pyruvate Kinase
M1 Type Pyruvate Kinase
M1-Type Pyruvate Kinase
M2 Type Pyruvate Kinase
M2-Type Pyruvate Kinase
Pyruvate Kinase L
Pyruvate Kinase, L-Type
Pyruvate Kinase, M-Type
Pyruvate Kinase, M1-Type
Pyruvate Kinase, M2-Type
Pyruvate Kinase, R-Type
R Type Pyruvate Kinase
R-Type Pyruvate Kinase
Tree number(s): D08.811.913.696.620.695
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011770
Scope note: ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Annotation: do not coord L-, R-, M-, M1- or M2-type pyruvate kinase with ISOENZYMES
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.1.40
Public MeSH Note: 65
History Note: 65
Related: Anemia, Hemolytic MeSH
DeCS ID: 12207
Unique ID: D011770
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09
Pyruvate Kinase - Preferred
Concept UI M0018293
Scope note ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Preferred term Pyruvate Kinase
Pyruvate Kinase L - Narrower
Concept UI M0018294
Preferred term Pyruvate Kinase L
Entry term(s) L Type Pyruvate Kinase
L-Type Pyruvate Kinase
Pyruvate Kinase, L-Type
M1-Type Pyruvate Kinase - Narrower
Concept UI M0018296
Preferred term M1-Type Pyruvate Kinase
Entry term(s) M1 Type Pyruvate Kinase
Pyruvate Kinase, M1-Type
M-Type Pyruvate Kinase - Narrower
Concept UI M0018295
Preferred term M-Type Pyruvate Kinase
Entry term(s) M Type Pyruvate Kinase
Pyruvate Kinase, M-Type
M2-Type Pyruvate Kinase - Narrower
Concept UI M0018297
Preferred term M2-Type Pyruvate Kinase
Entry term(s) M2 Type Pyruvate Kinase
Pyruvate Kinase, M2-Type
R-Type Pyruvate Kinase - Narrower
Concept UI M0018298
Preferred term R-Type Pyruvate Kinase
Entry term(s) Pyruvate Kinase, R-Type
R Type Pyruvate Kinase



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