DeCS

Descriptor English:

Quinacrine

Descriptor Spanish:

Quinacrina

Spanish from Spain

Descriptor	quinacrina
Entry term(s)	mepacrina
Scope note:	Derivado de la acridina que, en el pasado, se utilizó ampliamente como antimalárico pero que actualmente ha sido reemplazado por la cloroquina. Se ha usado como antihelmíntico y en el tratamiento de la giardiasis y efusiones malignas. Se utiliza en experimentación biológica celular como un inhibidor de la fosfolipasa A2.

Descriptor Portuguese:

Quinacrina

Descriptor French:

Mépacrine

Tree number(s):

D03.633.300.046.250.760

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D011796

Scope note:

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anticestodal Agents
Antimalarials
Antinematodal Agents
Antineoplastic Agents
Enzyme Inhibitors

Registry Number:

H0C805XYDE

CAS Type 1 Name:

1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-

DeCS ID:

12233

Unique ID:

D011796

NLM Classification:

QV 258