DeCS

Descriptor English:

Rifampin

Descriptor Spanish:

Rifampin

Spanish from Spain

Descriptor	rifampicina
Entry term(s)	rifampin
Scope note:	Antibiótico semisintético producido a partir de Streptomyces mediterranei. Tiene un amplio espectro antibacteriano, incluida la actividad contra varias formas de Mycobacterium. En organismos sensibles a este fármaco, inhibe la actividad de la ARN polimerasa dependiente del ADN formando un complejo estable con la enzima. De este modo, suprime la iniciación de la síntesis de ARN. La rifampicina es bactericida, y actúa tanto en microorganismos intracelulares como extracelulares.

Descriptor Portuguese:

Rifampina

Descriptor French:

Rifampicine

Tree number(s):

D03.633.400.811.700
D04.345.295.750.700

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D012293

Scope note:

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antibiotics, Antitubercular
Leprostatic Agents
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C19 Inducers
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP3A Inducers

Registry Number:

VJT6J7R4TR

CAS Type 1 Name:

Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-

DeCS ID:

12705

Unique ID:

D012293

NLM Classification:

QV 268

Documents indexed in the Virtual Health Library (VHL):

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