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Descriptor English: Thalidomide
Descriptor Spanish: Talidomida
Descriptor talidomida
Scope note: Piperidinil isoindol introducido originalmente como hipnótico no barbitúrico, pero que fue retirado del mercado por sus efectos teratogénicos. Ha sido reintroducido y utilizado en algunas enfermedades inmunológicas e inflamatorias. La talidomida tiene actividad inmunosupresora y antiangiogénica. Inhibe la liberación del FACTOR ALFA DE NECROSIS TUMORAL por los monocitos y modula la acción de otras citocinas.
Descriptor Portuguese: Talidomida
Descriptor French: Thalidomide
Entry term(s): Sedoval
Thalomid
Tree number(s): D02.241.223.805.810.800
D03.383.621.808.800
D03.633.100.513.750.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013792
Scope note: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Immunosuppressive Agents
Leprostatic Agents
Teratogens
Angiogenesis Inhibitors
Registry Number: 4Z8R6ORS6L
CAS Type 1 Name: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
DeCS ID: 14171
Unique ID: D013792
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Thalidomide - Preferred
Concept UI M0021267
Scope note A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Preferred term Thalidomide
Sedoval - Narrower
Concept UI M0332437
Preferred term Sedoval
Thalomid - Narrower
Concept UI M0476424
Preferred term Thalomid



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