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Descriptor English:

Thalidomide

Descriptor Spanish:

Talidomida

Spanish from Spain

Descriptor

talidomida

Scope note:

Piperidinil isoindol introducido originalmente como hipnótico no barbitúrico, pero que fue retirado del mercado por sus efectos teratogénicos. Ha sido reintroducido y utilizado en algunas enfermedades inmunológicas e inflamatorias. La talidomida tiene actividad inmunosupresora y antiangiogénica. Inhibe la liberación del FACTOR ALFA DE NECROSIS TUMORAL por los monocitos y modula la acción de otras citocinas.

Descriptor Portuguese:

Talidomida

Descriptor French:

Thalidomide

Tree number(s):

D02.241.223.805.810.800
D03.383.621.808.800
D03.633.100.513.750.750

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D013792

Scope note:

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Immunosuppressive Agents
Leprostatic Agents
Teratogens
Angiogenesis Inhibitors

Registry Number:

4Z8R6ORS6L

CAS Type 1 Name:

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-

DeCS ID:

14171

Unique ID:

D013792

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents