DeCS

Descriptor English:

Baclofen

Descriptor Spanish:

Baclofeno

Spanish from Spain

Descriptor	baclofeno
Entry term(s)	baclofen clorofenil GABA
Scope note:	Derivado del ÁCIDO GAMMA-AMINOBUTÍRICO que es agonista específico de los RECEPTORES DE GABA-B. Se emplea en el tratamiento de la ESPASTICIDAD MUSCULAR, especialmente la debida a LESIONES DE LA MÉDULA ESPINAL. Sus efectos terapéuticos son consecuencia de acciones en la médula espinal y supraespinal, generalmente la reducción de la transmisión excitatoria.

Descriptor Portuguese:

Baclofeno

Descriptor French:

Baclofène

Entry term(s):

Ba-34,647
Ba-34647
Ba34647
PCP-GABA
bêta-4-chlorophényl-GABA

Tree number(s):

D02.241.081.114.500.350.100

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D001418

Scope note:

A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Muscle Relaxants, Central
GABA-B Receptor Agonists

Registry Number:

H789N3FKE8

CAS Type 1 Name:

Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-

DeCS ID:

1442

Unique ID:

D001418

NLM Classification:

QV 140