DeCS

Descriptor English:

Ivermectin

Descriptor Spanish:

Ivermectina

Spanish from Spain

Descriptor

ivermectina

Scope note:

Mezcla principalmente de avermectina H2B1a (RN 71827-03-7) con algo de avermectina H2B1b (RN 70209-81-3), que son macrólidos de STREPTOMYCES avermitilis. Se une al canal de cloro dependiente del glutamato y causa un aumento de la permeabilidad e hiperpolarización de las células nerviosas y musculares. Interactúa también con otros CANALES DEL CLORO. Es un antiparasitario de amplio espectro activo frente a microfilarias de ONCHOCERCA VOLVULUS pero no frente a la forma adulta.

Descriptor Portuguese:

Ivermectina

Descriptor French:

Ivermectine

Entry term(s):

MK-933
MK933

Tree number(s):

D02.540.576.500.997

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D007559

Scope note:

A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antiparasitic Agents
Insecticides

Registry Number:

70288-86-7

CAS Type 1 Name:

Ivermectin

DeCS ID:

19221

Unique ID:

D007559

NLM Classification:

SF 918.I83