Search
Descriptor English: Prions
Descriptor Spanish: Priones
Descriptor priones
Entry term(s) prion
proteínas de priones
virus de la encefalopatía del visón
Scope note: Pequeñas partículas infecciosas proteináceas que resisten la inactivación por procedimientos que modifican los ÁCIDOS NUCLEICOS y que contienen una isoforma anormal de una proteína celular que es un componente importante y necesario. La isoforma anormal (precursora) es PrPSc (PROTEÍNAS PRPSC) y la isoforma celular PrPC (PROTEÍNAS PRPC). La secuencia primaria de aminoácidos de las dos isoformas es idéntica. Entre las enfermedades humanas producidas por priones se encuentran el SÍNDROME DE CREUTZFELDT-JAKOB, la ENFERMEDAD DE GERSTMANN-STRAUSSLER-SCHEINKER y el INSOMNIO FAMILIAR MORTAL.
Descriptor Portuguese: Príons
Descriptor French: Prions
Entry term(s): Agent de l'encéphalopathie transmissible du vison
Tree number(s): D12.776.785
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011328
Scope note: Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
PY pathogénicité
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
DeCS ID: 19524
Unique ID: D011328
NLM Classification: QU 55
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1985/05/10
Revision Date: 2020/05/27
Prions - Preferred
Concept UI M0017586
Preferred term Prions
Agent de l'encéphalopathie transmissible du vison - Narrower
Concept UI M0017585
Preferred term Agent de l'encéphalopathie transmissible du vison



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey