DeCS

Descriptor English:

Pro-Opiomelanocortin

Descriptor Spanish:

Proopiomelanocortina

Spanish from Spain

Descriptor	proopiomelanocortina
Entry term(s)	POMC opiocortina pro-opiocortina pro-opiomelanocortina proopiocortina
Scope note:	Proteína de 30 kDa que se sintetiza principalmente en la ADENOHIPOFISIS y el HIPOTÁLAMO. Se encuentra también en la piel y en otros tejidos periféricos. Dependiendo de las especies y los tejidos, la POMC es degradada por PROHORMONAS CONVERTASAS, dando lugar a varios péptidos activos, como la ACTH, la LIPOTROPINA BETA, las ENDORFINAS, las MELANOTROPINAS y otras (LPH GAMMA, PÉPTIDO DEL LÓBULO INTERMEDIO SIMILAR A LA CORTICOTROPINA, péptido N-terminal de la POMC (NPP)).

Descriptor Portuguese:

Pró-Opiomelanocortina

Descriptor French:

Pro-opiomélanocortine

Entry term(s):

ACTH Endorphin Precursor
ACTH beta Lipotropin Precursor
ACTH-Endorphin Precursor
ACTH-beta-Lipotropin Precursor
Corticotropin beta Lipotropin Precursor
Corticotropin-beta-Lipotropin Precursor
Endorphin ACTH Precursor
Endorphin-ACTH Precursor
Opiocortin
POMC
Pre POMC
Pre pro opiocortin
Pre-POMC
Pre-pro-opiocortin
Preproopiomelanocortin
Pro ACTH Endorphin
Pro Opio Melanocortin
Pro Opiocortin
Pro Opiomelanocortin
Pro-ACTH-Endorphin
Pro-Opio-Melanocortin
Pro-Opiocortin
Proopiocortin
Proopiomelanocortin

Tree number(s):

D06.472.699.327.935
D06.472.699.631.525.600
D12.644.400.400.935
D12.644.548.365.935
D12.644.548.691.525.690
D12.776.631.650.405.935
D12.776.811.800

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D011333

Scope note:

A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Registry Number:

66796-54-1

CAS Type 1 Name:

Opiomelanocortin, pro-

Previous Indexing:

Pituitary Hormones, Anterior (1966-1984)
Protein Precursors (1973-1984)

Public MeSH Note:

1985; PRE-PRO-OPIOCORTIN was indexed under PRO-OPIOMELANOCORTIN & PROTEIN PRECURSORS 1980-2007; OPIOCORTIN was indexed under PRO-OPIOMELANOCORTIN 1987-2007

Concept UI	M0017593
Scope note	A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Preferred term	Pro-Opiomelanocortin
Entry term(s)	ACTH Endorphin Precursor ACTH beta Lipotropin Precursor ACTH-Endorphin Precursor ACTH-beta-Lipotropin Precursor Corticotropin beta Lipotropin Precursor Corticotropin-beta-Lipotropin Precursor Endorphin ACTH Precursor Endorphin-ACTH Precursor POMC Pro ACTH Endorphin Pro Opio Melanocortin Pro Opiocortin Pro Opiomelanocortin Pro-ACTH-Endorphin Pro-Opio-Melanocortin Pro-Opiocortin Proopiocortin Proopiomelanocortin

Concept UI	M0084908
Preferred term	Preproopiomelanocortin
Entry term(s)	Pre POMC Pre pro opiocortin Pre-POMC Pre-pro-opiocortin

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