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Descriptor English: Camptothecin
Descriptor Spanish: Camptotecina
Descriptor camptotecina
Scope note: Alcaloide aislado de la madera del tronco del arbol chino, Camptotheca acuminata. Este compuesto inhibe selectivmente la enzima nuclear TOPOISOMERASAS DEL ADN TIPO I. Algunos compuestos semisintéticos análogos a la camptotecina han mostrado actividad antitumoral.
Descriptor Portuguese: Camptotecina
Descriptor French: Camptothécine
Tree number(s): D03.132.151
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002166
Scope note: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Antineoplastic Agents, Phytogenic
Topoisomerase I Inhibitors
Registry Number: XT3Z54Z28A
CAS Type 1 Name: 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
DeCS ID: 2198
Unique ID: D002166
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Camptothécine - Preferred
Concept UI M0003242
Preferred term Camptothécine



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