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Descriptor English: DNA, Satellite
Descriptor Spanish: ADN Satélite
Descriptor ADN satélite
Scope note: Secuencias altamente repetitivas de ADN que se encuentran en la HETEROCROMATINA, fundamentalmente cerca de los centrómeros. Están compuestos por secuencias simples (muy cortas) (ver REPETICIONES MINISATÉLITES) repetidas de una en una y muchas veces para formar grandes bloques de secuencias. Adicionalmente, tras la acumulación de mutaciones, estos bloques de repeticiones han sido repetidos ellos mismos en línea. El grado de repetición es del orden de 1000 a 10 millones en cada locus. Los loci son pocos, generalmente uno o dos por cromosoma. Se los denominó satélites ya que en gradientes de densidad, a menudo sedimentan como bandas satélite distintas separadas del grueso del ADN del genoma debido a su diferente COMPOSICIÓN DE BASES.
Descriptor Portuguese: DNA Satélite
Descriptor French: ADN satellite
Entry term(s): DNA, Satellite I
DNAs, Satellite
DNAs, Satellite I
I DNA, Satellite
I DNAs, Satellite
Satellite DNA
Satellite DNAs
Satellite I DNA
Satellite I DNAs
Tree number(s): D13.444.308.480
G02.111.570.080.708.800.150
G05.360.080.708.800.150
G05.360.340.024.220.150
G05.360.340.024.850.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004276
Scope note: Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: DNA (1966-1974)
Public MeSH Note: 80; was see under DNA 1975-79
History Note: 80(75); was see under DNA 1975-79
Related: Centromere MeSH
DeCS ID: 22160
Unique ID: D004276
NLM Classification: QU 58.5
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1974/11/11
Revision Date: 2008/07/08
DNA, Satellite - Preferred
Concept UI M0006691
Scope note Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.
Preferred term DNA, Satellite
Entry term(s) DNAs, Satellite
Satellite DNA
Satellite DNAs
Satellite I DNA - Narrower
Concept UI M0006692
Preferred term Satellite I DNA
Entry term(s) DNA, Satellite I
DNAs, Satellite I
I DNA, Satellite
I DNAs, Satellite
Satellite I DNAs



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