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Descriptor English: Fibrinogen
Descriptor Spanish: Fibrinógeno
Descriptor fibrinógeno
Entry term(s) factor I
factor I de la coagulación
Scope note: Glicoproteína plasmática coagulada por la trombina, compuesta de un dímero de tres pares no idénticos de cadenas polipeptídicas (alfa, beta, gamma) unidas por puentes disulfuro. La coagulación del fibrinógeno es un cambio sol-gel que implica complejas disposiciones moleculares: mientras que el fibrinógeno es desdoblado por la trombina para formar los polipéptidos A y B, la acción proteolítica de otras enzimas da lugar a diferentes productos de degradación del fibrinógeno.
Descriptor Portuguese: Fibrinogênio
Descriptor French: Fibrinogène
Entry term(s): Facteur I
Facteur I de la coagulation
Facteur I de la coagulation sanguine
Facteur de coagulation-1
Fibrinogène gamma
gamma-Fibrinogène
Tree number(s): D12.776.124.050.250
D12.776.124.125.500
D12.776.811.300
D23.119.490
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005340
Scope note: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Annotation: a blood coag factor: do not confuse entry term FACTOR I with COMPLEMENT FACTOR I
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Entry Combination: deficiency:Afibrinogenemia
Registry Number: 9001-32-5
CAS Type 1 Name: Fibrinogens
Related: Coagulants MeSH
Hémostatiques MeSH
DeCS ID: 22179
Unique ID: D005340
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/28
Fibrinogène - Preferred
Concept UI M0008430
Preferred term Fibrinogène
Entry term(s) Facteur I
Facteur I de la coagulation
Facteur I de la coagulation sanguine
Facteur de coagulation-1
Fibrinogène gamma - Narrower
Concept UI M0008431
Preferred term Fibrinogène gamma
Entry term(s) gamma-Fibrinogène



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