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| Descriptor English: | Platelet Factor 4 | ||||||
| Descriptor Spanish: |
Factor Plaquetario 4
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| Descriptor Portuguese: | Fator Plaquetário 4 | ||||||
| Descriptor French: | Facteur-4 plaquettaire | ||||||
| Entry term(s): |
Antiheparin Factor CXCL4 Chemokine CXCL4, Chemokine Chemokine CXCL4 Chemokine, CXCL4 Heparin Neutralizing Protein PF4 (Platelet Factor 4) gamma Thromboglobulin gamma-Thromboglobulin |
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| Tree number(s): |
D12.644.276.374.200.120.900 D12.776.124.125.720 D12.776.467.374.200.120.900 D23.119.940 D23.125.300.120.900 D23.469.200.120.900 D23.529.374.200.120.900 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D010978 | ||||||
| Scope note: | A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Coagulants |
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| Registry Number: | 37270-94-3 | ||||||
| CAS Type 1 Name: | Blood platelet factor 4 | ||||||
| Previous Indexing: |
Blood Coagulation Factors (1973-1975) Blood Platelets (1974-1975) Glycoproteins (1974-1975) |
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| Public MeSH Note: | 84; was see under BLOOD COAGULATION FACTORS 1976-83 |
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| History Note: | 84(76); was see under BLOOD COAGULATION FACTORS 1976-83 |
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| DeCS ID: | 22259 | ||||||
| Unique ID: | D010978 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1984/01/01 | ||||||
| Date of Entry: | 1975/07/25 | ||||||
| Revision Date: | 2007/07/09 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Platelet Factor 4
- Preferred
| Concept UI |
M0017019 |
| Scope note | A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C. |
| Preferred term | Platelet Factor 4 |
| Entry term(s) |
Antiheparin Factor CXCL4 Chemokine CXCL4, Chemokine Chemokine CXCL4 Chemokine, CXCL4 Heparin Neutralizing Protein PF4 (Platelet Factor 4) gamma Thromboglobulin gamma-Thromboglobulin |
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