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Descriptor English: Lovastatin
Descriptor Spanish: Lovastatina
Descriptor lovastatina
Entry term(s) mevinolina
Scope note: Metabolito fúngico aislado de cultivos de Aspergillus terreus. El compuesto es un potente agente anticolesterémico. Inhibe la 3-hidroxi-3-metilglutaril coenzima A reductasa (HIDROXIMETILGLUTARIL COA REDUCTASAS), que es la enzima limitante de la velocidad en la biosíntesis del colesterol. Estimula también la producción de receptores de las lipoproteínas de baja densidad del hígado.
Descriptor Portuguese: Lovastatina
Descriptor French: Lovastatine
Entry term(s): MK-803
MK803
Tree number(s): D02.455.426.559.847.638.400
D04.615.638.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008148
Scope note: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registry Number: 9LHU78OQFD
CAS Type 1 Name: Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
DeCS ID: 22932
Unique ID: D008148
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1988/01/01
Date of Entry: 1987/05/04
Revision Date: 2015/06/23
Lovastatine - Preferred
Concept UI M0012707
Preferred term Lovastatine
MK-803 - Narrower
Concept UI M0354780
Preferred term MK-803
Entry term(s) MK803



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