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Descriptor in English: Dideoxynucleosides
Descriptor in Spanish: Didesoxinucleósidos
Descriptor in Portuguese: Didesoxinucleosídeos
Descriptor in French: Didéoxynucléosides
Entry term(s): 2',3' Dideoxynucleosides
2',3'-Dideoxynucleosides
Dideoxyribonucleosides
ddNus
Tree number(s): D13.570.230.500
Scope note: Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Annotation: antivirals & antimetabolites
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 89
DeCS UI: 23607
Descriptor UI: D015224
Date Established: 1989/01/01
Date of Entry: 1988/05/12
Revision Date: 1995/06/08
Dideoxynucleosides - Preferred
Concept UI M0023387
Scope note Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Preferred term Dideoxynucleosides
Entry term(s) ddNus
2',3'-Dideoxynucleosides - Narrower
Concept UI M0023388
Preferred term 2',3'-Dideoxynucleosides
Entry term(s) 2',3' Dideoxynucleosides
Dideoxyribonucleosides - Narrower
Concept UI M0023389
Preferred term Dideoxyribonucleosides



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