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Descriptor English: Neprilysin
Descriptor Spanish: Neprilisina
Descriptor neprilisina
Entry term(s) antígeno CALLA
antígenos CD10
antígenos comunes de la leucemia linfoblástica aguda
encefalina dipeptidil carboxipeptidasa
encefalinasa
endopeptidasa 24.11
endopeptidasa neutra
metaloendopeptidasa de membrana
proteinasa neutra de célula renal con borde en cepillo
Scope note: Enzima que es el constituyente principal de las membranas de las células renales con borde en cepillo y también está presente, en menor grado, en el encéfalo y otros tejidos. Cataliza preferentemente la escisión del grupo amino de los residuos hidrófobos de la cadena B de la insulina, así como de péptidos opioides y de otros péptidos biológicamente activos. La enzima es inhibida principalmente por el EDTA, el fosforamidón y el tiorfano, y es reactivada por el zinc. La neprilisina es idéntica al antígeno común de la leucemia linfoblástica aguda (antígeno CALLA), un marcador importante en el diagnóstico de la leucemia linfocítica aguda humana. No existe relación con la PLANTA CALLA.
Descriptor Portuguese: Neprilisina
Descriptor French: Néprilysine
Entry term(s): Antigène CALLA
Antigène CD10
Antigènes de la leucémie aigüe lymphoblastique
Atriopeptidase
CD10
Endopeptidase neutre
Endopeptidase neutre 24.11
Enkephalin Dipeptidyl Carboxypeptidase
Enképhalinase
Métallo-endopeptidase membranaire
Protéinase neutre de la bordure en brosse rénale
Thermolysin-Like Metalloendopeptidase
YGG-Forming enzyme
Tree number(s): D08.811.277.656.300.480.600
D08.811.277.656.675.374.600
D23.050.285.550
D23.101.140.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015260
Scope note: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 3.4.24.11
DeCS ID: 23757
Unique ID: D015260
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/18
Revision Date: 2017/05/24
Néprilysine - Preferred
Concept UI M0023500
Preferred term Néprilysine
Entry term(s) Antigène CALLA
Antigène CD10
Antigènes de la leucémie aigüe lymphoblastique
Atriopeptidase
CD10
Endopeptidase neutre
Endopeptidase neutre 24.11
Enkephalin Dipeptidyl Carboxypeptidase
Enképhalinase
Métallo-endopeptidase membranaire
Protéinase neutre de la bordure en brosse rénale
Thermolysin-Like Metalloendopeptidase
YGG-Forming enzyme



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