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Descriptor English: Protein Engineering
Descriptor Spanish: Ingeniería de Proteínas
Descriptor ingeniería de proteínas
Entry term(s) ingeniería genética de proteínas
Scope note: Procedimientos mediante los que se cambia o se crea, in vitro, la función y estructura de las proteínas, alterando las existentes o sintetizando nuevos genes estructurales que dirigen la síntesis de proteínas con las propiedades deseadas. Esos procedimientos pueden incluir el diseño de MODELOS MOLECULARES de proteínas utilizando GRÁFICOS POR ORDENADOR u otras técnicas de modelado molecular; la MUTAGÉNESIS ESPECÍFICA DE SITIO de genes existentes; y técnicas de EVOLUCIÓN MOLECULAR DIRIGIDA para crear nuevos genes.
Descriptor Portuguese: Engenharia de Proteínas
Descriptor French: Ingénierie des protéines
Entry term(s): Engineering, Protein
Engineering, Protein Genetic
Genetic Engineering of Proteins
Genetic Engineering, Protein
Protein Genetic Engineering
Proteins, Genetic Engineering
Tree number(s): E05.393.420.601
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015202
Scope note: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
Allowable Qualifiers: CL classification
EC economics
ES ethics
HI history
IS instrumentation
LJ legislation & jurisprudence
MT methods
SN statistics & numerical data
ST standards
TD trends
VE veterinary
Previous Indexing: Genes, Structural (1983-1988)
Genetic Intervention (1983-1988)
Mutation (1983-1988)
Public MeSH Note: 89
History Note: 89
Related: Directed Molecular Evolution MeSH
Mutagenesis, Site-Directed MeSH
DeCS ID: 23805
Unique ID: D015202
NLM Classification: QU 55.95
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/04/30
Revision Date: 2004/07/30
Protein Engineering - Preferred
Concept UI M0023358
Scope note Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
Preferred term Protein Engineering
Entry term(s) Engineering, Protein
Engineering, Protein Genetic
Genetic Engineering of Proteins
Genetic Engineering, Protein
Protein Genetic Engineering
Proteins, Genetic Engineering



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