DeCS

Descriptor English:

DNA Restriction Enzymes

Descriptor Spanish:

Enzimas de Restricción del ADN

Spanish from Spain

Descriptor	enzimas de restricción del ADN
Entry term(s)	endonucleasas de restricción
Scope note:	Enzimas que forman parte de los sistemas de restricción-modificación. Catalizan la escisión endonucleolítica de secuencias de ADN que no poseen el patrón de metilación específico de la especie en el ADN de la célula huésped. La escisión da lugar a fragmentos bicatenarios aleatorios o específicos con 5'-fosfatos terminales. La función de las enzimas de restricción es destruir cualquier ADN extraño que invada la célula huésped. La mayoría han sido estudiadas en sistemas bacterianos, pero algunas se han encontrado en organismos eucariotas. También se han usado como herramientas en la disección sistemática y la cartografía de los cromosomas, en la determinación de la secuencia de bases de ADN, y han hecho posible cortar y recombinar genes de un organismo en el genoma de otro. EC 3.21.1.

Descriptor Portuguese:

Enzimas de Restrição do DNA

Descriptor French:

DNA restriction enzymes

Entry term(s):

DNA Restriction Enzyme
Endonuclease, Restriction
Endonucleases, Restriction
Enzymes, DNA Restriction
Restriction Endonuclease
Restriction Endonucleases
Restriction Enzyme, DNA
Restriction Enzymes, DNA

Tree number(s):

D08.811.150.280
D08.811.277.352.335.350.300
D08.811.277.352.355.325.300

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D004262

Scope note:

Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.

Annotation:

DNA restriction enzyme used as a DNA marker: coord probably NIM with GENETIC MARKER (IM)

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M0006671
Scope note	Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Preferred term	DNA Restriction Enzymes
Entry term(s)	DNA Restriction Enzyme Endonuclease, Restriction Endonucleases, Restriction Enzymes, DNA Restriction Restriction Endonuclease Restriction Endonucleases Restriction Enzyme, DNA Restriction Enzymes, DNA

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