DeCS

Descriptor English:

Histocompatibility Antigens Class II

Descriptor Spanish:

Antígenos de Histocompatibilidad Clase II

Spanish from Spain

Descriptor	antígenos de histocompatibilidad de clase II
Entry term(s)	antígeno I-A antígeno IA antígeno de histocompatibilidad de clase II antígeno de tipo Ia antígeno principal de histocompatibilidad de clase II antígenos Ia antígenos asociados a la inmunidad antígenos asociados a la respuesta inmunitaria antígenos asociados a respuesta inmunitaria antígenos de clase II antígenos de la respuesta inmunitaria antígenos de respuesta inmunitaria antígenos de tipo Ia molécula del CPH de clase II moléculas MHC II moléculas MHC de clase II moléculas de clase II del MHC moléculas de clase II del complejo principal de histocompatibilidad moléculas del CPH de clase II moléculas del CPH-II moléculas del complejo principal de histocompatibilidad de clase II proteínas de clase II del MHC proteínas del CPH de clase II péptido del CPH de clase II péptidos MHC II péptidos MHC de clase II péptidos del CPH de clase II péptidos del CPH-II
Scope note:	Glicoproteínas (alfa y beta) transmembranales grandes, sin enlace covalentemente. Ambas cadenas pueden ser polimórficas aunque hay más variación estructural en las cadenas beta. Los antígenos de clase II en humanos se conocen como ANTÍGENOS HLA-D y se codifican por un gen en el cromosoma 6. En ratones, dos genes llamados IA e IE sobre el cromosoma 17 codifican para los antígenos H-2. Los antígenos se encuentran sobre los linfocitos B, macrófagos, células epidérmicas y espermáticas, y se piensa que median la competencia y la cooperación celular en la respuesta inmune. El término antígenos IA, usado para referirse sólo a las proteínas codificadas por los genes IA en los ratones, ahora se usa como un término genérico para cualquier antígeno de histocompatibilidad de clase II.

Descriptor Portuguese:

Antígenos de Histocompatibilidade Classe II

Descriptor French:

Antigènes d'histocompatibilité de classe II

Entry term(s):

Antigen, Class II
Antigen, I-A
Antigen, IA
Antigens, Class II
Antigens, Ia
Antigens, Ia-Like
Antigens, Immune Response
Antigens, Immune-Associated
Antigens, Immune-Response-Associated
Class II Antigen
Class II Antigens
Class II Histocompatibility Antigen
Class II Histocompatibility Antigens
Class II MHC Proteins
Class II Major Histocompatibility Antigen
Class II Major Histocompatibility Antigens
Class II Major Histocompatibility Molecules
I A Antigen
I-A Antigen
I-A-Antigen
IA Antigen
Ia Antigens
Ia Like Antigens
Ia-Like Antigen
Ia-Like Antigens
Immune Associated Antigens
Immune Response Antigens
Immune Response Associated Antigens
Immune-Associated Antigens
Immune-Response-Associated Antigens
MHC Class II Molecule
MHC Class II Molecules
MHC II Molecules
MHC II Peptide
MHC II Peptides
MHC-II Molecules
Molecules, MHC-II
Peptides, MHC II

Tree number(s):

D12.776.395.550.509
D12.776.543.550.440
D23.050.301.500.400
D23.050.705.552.410

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000949

Scope note:

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

Annotation:

human & animal; see also HLA ANTIGENS & specifics for human

Allowable Qualifiers:

AD administration & dosage
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M0001420
Scope note	Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Preferred term	Histocompatibility Antigens Class II
Entry term(s)	Antigen, Class II Antigen, I-A Antigen, IA Antigens, Class II Antigens, Ia Antigens, Ia-Like Antigens, Immune Response Antigens, Immune-Response-Associated Class II Antigen Class II Antigens Class II Histocompatibility Antigen Class II Histocompatibility Antigens Class II MHC Proteins Class II Major Histocompatibility Antigen Class II Major Histocompatibility Antigens Class II Major Histocompatibility Molecules I A Antigen I-A Antigen I-A-Antigen IA Antigen Ia Antigens Ia Like Antigens Ia-Like Antigen Ia-Like Antigens Immune Response Antigens Immune Response Associated Antigens Immune-Response-Associated Antigens MHC Class II Molecule MHC Class II Molecules MHC II Molecules MHC II Peptide MHC II Peptides MHC-II Molecules Molecules, MHC-II Peptides, MHC II

Concept UI	M0001421
Preferred term	Immune-Associated Antigens
Entry term(s)	Antigens, Immune-Associated Immune Associated Antigens

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