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Descriptor English: | Integrins | ||||||
Descriptor Spanish: |
Integrinas
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Descriptor Portuguese: | Integrinas | ||||||
Descriptor French: | Intégrines | ||||||
Tree number(s): |
D12.776.543.750.705.408 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D016023 | ||||||
Scope note: | A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. |
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Annotation: | prefer specifics |
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Allowable Qualifiers: |
AD administration et posologie AG agonistes AI antagonistes et inhibiteurs AN analyse BI biosynthèse BL sang CF liquide cérébrospinal CH composition chimique CL classification DE effets des médicaments et des substances chimiques DF déficit GE génétique HI histoire IM immunologie IP isolement et purification ME métabolisme PH physiologie RE effets des radiations TU usage thérapeutique UL ultrastructure |
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Related: |
Molécules d'adhérence cellulaire
MeSH | ||||||
DeCS ID: | 24746 | ||||||
Unique ID: | D016023 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 1990/01/01 | ||||||
Date of Entry: | 1989/07/07 | ||||||
Revision Date: | 2020/05/27 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines
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