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Descriptor English: Killer Cells, Lymphokine-Activated
Descriptor Spanish: Células Asesinas Activadas por Linfocinas
Descriptor células asesinas activadas por linfocinas
Entry term(s) células LAK
células asesinas linfocino-activadas
Scope note: Linfocitos citolíticos con capacidad específica para destruir las células tumorales recientes que son resistentes a las células asesinas naturales (células NK). Son células asesinas naturales activadas por la INTERLEUCINA-2, sin restricción del COMPLEJO PRINCIPAL DE HISTOCOMPATIBILIDAD ni necesidad de estimulación antigénica. Las células asesinas activadas por linfocinas (células LAK) se utilizan en la INMUNOTERAPIA ADOPTIVA en los pacientes con cáncer.
Descriptor Portuguese: Células Matadoras Ativadas por Linfocina
Descriptor French: Cellules LAK
Entry term(s): Cell, LAK
Cell, Lymphokine-Activated Killer
Cells, LAK
Cells, Lymphokine-Activated Killer
Killer Cell, Lymphokine-Activated
Killer Cells, Lymphokine Activated
LAK Cell
LAK Cells
Lymphokine Activated Killer Cells
Lymphokine-Activated Killer Cell
Lymphokine-Activated Killer Cells
Tree number(s): A11.118.637.555.283.500
A11.118.637.555.567.537.500
A15.145.229.637.555.283.500
A15.145.229.637.555.567.537.500
A15.382.490.555.283.500
A15.382.490.555.567.537.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015979
Scope note: Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.
Annotation: if subpopulations are discussed, coordinate IM with LYMPHOCYTE SUBSETS (IM)
Allowable Qualifiers: CH chemistry
CL classification
CY cytology
DE drug effects
EN enzymology
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
Previous Indexing: Killer Cells, Natural (1982-1989)
Public MeSH Note: 90
History Note: 90
Related: Immunotherapy, Adoptive MeSH
Interleukin-2 MeSH
DeCS ID: 24762
Unique ID: D015979
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/06/26
Revision Date: 2008/07/08
Killer Cells, Lymphokine-Activated - Preferred
Concept UI M0024414
Scope note Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.
Preferred term Killer Cells, Lymphokine-Activated
Entry term(s) Cell, LAK
Cell, Lymphokine-Activated Killer
Cells, LAK
Cells, Lymphokine-Activated Killer
Killer Cell, Lymphokine-Activated
Killer Cells, Lymphokine Activated
LAK Cell
LAK Cells
Lymphokine Activated Killer Cells
Lymphokine-Activated Killer Cell
Lymphokine-Activated Killer Cells



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