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Descriptor English: 1-Methyl-4-phenylpyridinium
Descriptor Spanish: 1-Metil-4-fenilpiridinio
Descriptor 1-metil-4-fenilpiridinio
Entry term(s) ciperquat
Scope note: Metabolito neurotóxico activo de la 1-METIL-4-FENIL-1,2,3,6-TETRAHIDROPIRIDINA. Este compuesto reduce los niveles de dopamina, inhibe la biosíntesis de las catecolaminas, produce disminución cardíaca de norepinefrina e inactiva la tirosina hidroxilasa. Estos y otros efectos tóxicos provocan el cese de la fosforilacion oxidativa, depleción de ATP y muerte celular. Este compuesto, que está relacionado con el PARAQUAT, tambien se ha utilizado como herbicida.
Descriptor Portuguese: 1-Metil-4-fenilpiridínio
Descriptor French: 1-Méthyl-4-phényl-pyridinium
Entry term(s): 1 Methyl 4 phenylpyridine
1 Methyl 4 phenylpyridinium
1 Methyl 4 phenylpyridinium Chloride
1 Methyl 4 phenylpyridinium Ion
1-Methyl-4-phenylpyridine
1-Methyl-4-phenylpyridinium Chloride
1-Methyl-4-phenylpyridinium Ion
Cyperquat
N Methyl 4 phenylpyridine
N-Methyl-4-phenylpyridine
N-Methyl-4-phenylpyridinium
Tree number(s): D03.383.725.762.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015655
Scope note: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Herbicides
Registry Number: R865A5OY8J
CAS Type 1 Name: Pyridinium, 1-methyl-4-phenyl-
Previous Indexing: Pyridinium Compounds (1968-1989)
Public MeSH Note: 90
History Note: 90
Related: MPTP Poisoning MeSH
DeCS ID: 24778
Unique ID: D015655
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/16
Revision Date: 2016/05/27
1-Methyl-4-phenylpyridinium - Preferred
Concept UI M0023993
Scope note An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Preferred term 1-Methyl-4-phenylpyridinium
Entry term(s) 1 Methyl 4 phenylpyridine
1 Methyl 4 phenylpyridinium
1 Methyl 4 phenylpyridinium Ion
1-Methyl-4-phenylpyridine
1-Methyl-4-phenylpyridinium Ion
Cyperquat
N Methyl 4 phenylpyridine
N-Methyl-4-phenylpyridine
N-Methyl-4-phenylpyridinium
1-Methyl-4-phenylpyridinium Chloride - Narrower
Concept UI M0331307
Preferred term 1-Methyl-4-phenylpyridinium Chloride
Entry term(s) 1 Methyl 4 phenylpyridinium Chloride



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