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Descriptor English: Chlormethiazole
Descriptor Spanish: Clormetiazol
Descriptor clormetiazol
Scope note: Sedante y anticonvulsionante utilizado frecuentemente en el tratamiento de la deshabituación alcohólica. El clormetiazol también está indicado como agente neuroprotector. El mecanismo de su acción terapéutica todavía no está totalmente aclarado, aunque se sabe que potencia la respuesta de los receptores del ÁCIDO GAMMA-AMINOBUTÍRICO y que también puede afectar a los receptores de glicina.
Descriptor Portuguese: Clormetiazol
Descriptor French: Clométhiazole
Entry term(s): Clomethiazole
Distraneurin
Tree number(s): D02.886.675.180
D03.383.129.708.180
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002719
Scope note: A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticonvulsants
Hypnotics and Sedatives
Neuroprotective Agents
GABA Modulators
Registry Number: 0C5DBZ19HV
CAS Type 1 Name: Thiazole, 5-(2-chloroethyl)-4-methyl-
Previous Indexing: Hypnotics and Sedatives (1966-1967)
Thiazoles (1966-1967)
Public MeSH Note: 68; CHLORETHIAZOLE was see CHLORMETHAZOLE 1975-95
History Note: 68; CHLORETHIAZOLE was see CHLORMETHAZOLE 1975-95
DeCS ID: 2764
Unique ID: D002719
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1968/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/28
Chlormethiazole - Preferred
Concept UI M0004156
Scope note A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.
Preferred term Chlormethiazole
Entry term(s) Clomethiazole
Distraneurin - Narrower
Concept UI M0004157
Preferred term Distraneurin



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