DeCS

Descriptor English:

Transglutaminases

Descriptor Spanish:

Transglutaminasas

Spanish from Spain

Descriptor	transglutaminasas
Entry term(s)	glutaminil-péptido gammaglutamiltransferasas proteína-glutamina gammaglutamiltransferasas transglutaminasa
Scope note:	Enzimas que catalizan el enlace cruzado de proteínas a una glutamina en una cadena y a LISINA en otra cadena. Comprenden la transglutaminasa de los queratinocitos (TGM1 o TGK), la transglutaminasa tisular (TGM2 o TGC), la transglutaminasa plasmática implicada en la coagulación (FACTOR XIII y FACTOR XIIIa), la transglutaminasa del folículo piloso y la transglutaminasa prostática. Aunque tienen diferentes estructuras comparten un sitio activo (YGQCW) y la estricta dependencia del CALCIO.

Descriptor Portuguese:

Transglutaminases

Descriptor French:

Transglutaminases

Entry term(s):

Glutaminyl-peptide gamma-glutamyltransférases

Tree number(s):

D08.811.913.050.200.800

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D011503

Scope note:

Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

Annotation:

distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available

Allowable Qualifiers:

AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine

Registry Number:

EC 2.3.2.13

CAS Type 1 Name:

Protein-glutamine:amine gamma-glutamyltransferase

DeCS ID:

27787

Unique ID:

D011503

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

1986/01/01