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Descriptor English: alpha 1-Antitrypsin
Descriptor Spanish: alfa 1-Antitripsina
Descriptor alfa 1-antitripsina
Entry term(s) inhibidor de la proteasa alfa-1
inhibidor de la proteinasa alfa 1
inhibidor de tripsina alfa 1-antitripsina
Scope note: Glicoproteína plasmática miembro de las superfamilia serpina que inhibe la TRIPSINA, ELASTASA DE NEUTRÓFILOS y otras ENZIMAS PROTEOLÍTICAS. Se la denomina comúnmente inhibidor de alfa-1 proteinasa (A1P1) y existe en más de 30 formas variantes bioquímicas diferentes conocidas de modo colectivo como sistema Pi (inhibidor de proteasa). La deficiencia hereditaria en A1P1 se asocia con ENFISEMA PULMONAR.
Descriptor Portuguese: alfa 1-Antitripsina
Descriptor French: alpha-1-Antitrypsine
Entry term(s): 1-Antiproteinase, alpha
A1PI
Antiprotease, alpha 1
Inhibitor, alpha 1-Protease
Inhibitor, alpha 1-Proteinase
Prolastin
Serpin A1
Trypsin Inhibitor, alpha 1 Antitrypsin
Trypsin Inhibitor, alpha 1-Antitrypsin
Zemaira
alpha 1 Antiprotease
alpha 1 Antiproteinase
alpha 1 Antitrypsin
alpha 1 Protease Inhibitor
alpha 1 Proteinase Inhibitor
alpha 1-Antiproteinase
alpha 1-Protease Inhibitor
alpha 1-Proteinase Inhibitor
Tree number(s): D12.644.861.035
D12.776.124.050.070
D12.776.124.790.106.085
D12.776.377.715.085.085
D12.776.395.068
D12.776.872.035
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000515
Scope note: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:alpha 1-Antitrypsin Deficiency
Pharm Action: Trypsin Inhibitors
Serine Proteinase Inhibitors
Public MeSH Note: 74
History Note: 74
Related: alpha 1-Antitrypsin Deficiency MeSH
DeCS ID: 27940
Unique ID: D000515
NLM Classification: WH 400
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/23
alpha 1-Antitrypsin - Preferred
Concept UI M0000780
Scope note Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Preferred term alpha 1-Antitrypsin
Entry term(s) 1-Antiproteinase, alpha
A1PI
Antiprotease, alpha 1
Inhibitor, alpha 1-Protease
Inhibitor, alpha 1-Proteinase
Serpin A1
Trypsin Inhibitor, alpha 1 Antitrypsin
Trypsin Inhibitor, alpha 1-Antitrypsin
alpha 1 Antiprotease
alpha 1 Antiproteinase
alpha 1 Antitrypsin
alpha 1 Protease Inhibitor
alpha 1 Proteinase Inhibitor
alpha 1-Antiproteinase
alpha 1-Protease Inhibitor
alpha 1-Proteinase Inhibitor
Prolastin - Narrower
Concept UI M0372282
Preferred term Prolastin
Zemaira - Narrower
Concept UI M0462993
Preferred term Zemaira



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