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Descriptor English: Spectrin
Descriptor Spanish: Espectrina
Descriptor espectrina
Scope note: Proteína hidrosoluble de alto peso molecular (220-250 kDa) que puede ser extraída de fantasmas eritrocitarios en tampones de baja fuerza iónica. La proteína no contiene lípidos ni carbohidratos, es la especie predominante de las proteínas de membrana de los eritrocitos periféricos y existe como un recubrimiento fibroso en la membrana de la superficie interna del citoplasma.
Descriptor Portuguese: Espectrina
Descriptor French: Spectrine
Entry term(s): alpha Spectrin
alpha-Spectrin
beta Spectrin
beta-Spectrin
Tree number(s): D12.776.220.980
D12.776.543.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013049
Scope note: A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 12634-43-4
CAS Type 1 Name: Spectrins
Previous Indexing: Blood Proteins (1966-1976)
Cell Membrane (1966-1975)
Erythrocytes (1966-1975)
Public MeSH Note: 84; was see under MEMBRANE PROTEINS 1978-83, was see under BLOOD PROTEINS 1977
History Note: 84(77); was see under MEMBRANE PROTEINS 1978-83, was see under BLOOD PROTEINS 1977
DeCS ID: 29583
Unique ID: D013049
NLM Classification: WH 400
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1976/04/16
Revision Date: 2017/07/03
Spectrin - Preferred
Concept UI M0020228
Scope note A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.
Preferred term Spectrin
alpha-Spectrin - Narrower
Concept UI M0020226
Preferred term alpha-Spectrin
Entry term(s) alpha Spectrin
beta-Spectrin - Narrower
Concept UI M0020227
Preferred term beta-Spectrin
Entry term(s) beta Spectrin



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