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Descriptor English:

Didanosine

Descriptor Spanish:

Didanosina

Spanish from Spain

Descriptor	didanosina
Entry term(s)	2',3'-didesoxinosina ddI (antiviral) didesoxinosina
Scope note:	Didesoxinucleósido en el que el grupo 3'-hidroxilo de la molécula de azúcar ha sido reemplazado por un hidrógeno. Esta modificación impide la formación de los enlaces fosfodiéster necesarios para formar las cadenas de ácido nucleico. La dinadosina es un potente inhibidor de la replicación del VIH, y actúa como terminal de la cadena del ADN viral al unirse a la transcriptasa inversa; el ddi es entonces metabolizado a trifosfato de didesoxiadenosina, que es su metabolito putativo activo.

Descriptor Portuguese:

Didanosina

Descriptor French:

Didéoxyinosine

Tree number(s):

D03.633.100.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D016049

Scope note:

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents

Registry Number:

K3GDH6OH08

CAS Type 1 Name:

Inosine, 2',3'-dideoxy-

DeCS ID:

30328

Unique ID:

D016049

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents