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Descriptor English: Lactase-Phlorizin Hydrolase
Descriptor Spanish: Lactasa-Florizina Hidrolasa
Descriptor lactasa-floricina hidrolasa
Entry term(s) floretina-glucosidasa
florizina hidrolasa
glicosilceramidasa
Scope note: Proteína multifuncional que contiene dos dominios enzimáticos. El primer dominio (EC 3.2.1.62) hidroliza la glicosil-N-acilesfingosina dando lugar a un azúcar y N-acilesfingosina. El segundo dominio (EC 3.2.1.108) hidroliza la LACTOSA y se encuentra en la membrana del ribete en cepillo de los enterocitos. La pérdida de actividad de esta enzima en el ser humano origina la INTOLERANCIA A LA LACTOSA.
Descriptor Portuguese: Lactase-Florizina Hidrolase
Descriptor French: Lactase-phlorizin hydrolase
Entry term(s): Glycosyl-céramidase
Glycosylcéramidase
Lactase glycosyl-céramidase
Lactase-phlorizine hydrolase
Lactase-phlorétine hydrolase
Phlorizine hydrolase
Phlorétine glucosidase
Tree number(s): D08.811.277.450.410.100.500.500
D08.811.277.450.420.475
D08.811.641.761
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010694
Scope note: A multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.62
Related: Intolérance au lactose MeSH
DeCS ID: 30404
Unique ID: D010694
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2018/05/21
Lactase-phlorizin hydrolase - Preferred
Concept UI M0016614
Preferred term Lactase-phlorizin hydrolase
Entry term(s) Glycosyl-céramidase
Glycosylcéramidase
Lactase glycosyl-céramidase
Lactase-phlorizine hydrolase
Lactase-phlorétine hydrolase
Phlorizine hydrolase
Phlorétine glucosidase



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