DeCS

Descriptor English:

Thiotepa

Descriptor Spanish:

Tiotepa

Spanish from Spain

Descriptor	tiotepa
Entry term(s)	tio-TEPA tiofosfamida trietilenotiofosforamida
Scope note:	Agente alquilante antineoplásico muy tóxico utilizado también como esterilizante de insectos. Produce daños en la piel, aparato gastrointestinal, SNC y médula ósea. Según el Fourth Annual Report on Carcinogens (NTP 85-002, 1985), se puede razonablemente anticipar que la tiotepa es carcinógeno (Merck Index, 11th ed).

Descriptor Portuguese:

Tiotepa

Descriptor French:

Thiotépa

Entry term(s):

AI3-24916
AI324916
NSC-6396
NSC6396

Tree number(s):

D02.705.672.875
D03.383.097.217.935.960

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D013852

Scope note:

A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antineoplastic Agents, Alkylating
Myeloablative Agonists

Registry Number:

905Z5W3GKH

CAS Type 1 Name:

Aziridine, 1,1',1''-phosphinothioylidynetris-

DeCS ID:

30423

Unique ID:

D013852

NLM Classification:

QV 269